Effect of thio TEPA on the synthesis of protein and nucleic acids in tumor-bearing mice.

Treatment with three daily doses (3-10 gg/gm each) of thioTEPA inhibited incorporation of radioactive glycine and lysine into protein, of glycine into acid-soluble nucleotides, and of glycine, formate, adenine, and orotic acid into nucleic acids of L-1 mouse tumor in a majority of experiments. In tumors from mice having other treatment schedules and in livers from all groups no definite change in incorporation of these labeled metabolites was observed.